Used primarily for maintenance treatment of COPD or asthma but is not a preferred agent in either disease; also used in apnea of prematurity not responding to other therapies Aminophylline is converted to theophylline systemically; 1 mg aminophylline = 0.8 mg theophylline doi: 10.1378/chest.107.5_supplement.206s. Delivered either orally or intravenously, theophylline acts as a bronchodilator to reduce airway reactivity that leads to wheezing and shortness of breath. I have had several patients come to me who were taking theophylline and were reluctant to stop, but unless further studies confirm the small decrease in hospitalizations, I will no longer prescribe theophylline for my COPD patients. Comment. Many people with COPD have mild forms of the disease for which little therapy is needed other than smoking cessation. It is usually taken by mouth as a pill. Even for more advanced stages of disease, effective therapy is available that can control symptoms, slow progression, reduce your risk of complications and exacerbations, and improve your ability to lead an active life. A blood test must be done to monitor your theophylline level to make sure the drug level is … Author J Ramsdell 1 Affiliation 1 University of California at San Diego, USA. Treatment. Use of theophylline in the treatment of COPD Chest. Theophylline is used to treat lung diseases such as asthma and COPD (bronchitis, emphysema).It must be used regularly to prevent wheezing and shortness of breath. Theophylline is a drug used in combination with other medications for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Theophylline has no role in treating patients with chronic stable COPD or acute COPD exacerbations. * Which of the following best describes the role of theophylline in COPD treatment? Use of theophylline in the treatment of COPD. Drugs used to treat COPD The following list of medications are in some way related to, or used in the treatment of this condition. a. routinely indicated in moderate to very severe COPD b. use limited by narrow therapeutic profile and drug-drug interaction potential c. a potent bronchodilator d. available only in parenteral form Oral theophylline has been used as a bronchodilator to treat COPD for decades; however, to achieve modest bronchodilatation through phosphodiesterase inhibition, blood concentrations (10-20 mg/L) are required that are associated with adverse effects. 1995 May;107(5 Suppl):206S-209S. Breathlessness is common in patients with chronic obstructive pulmonary disease (COPD) and often is the reason that the individual patient seeks medical attention. Theophylline Theophylline is a bronchodilator that is not commonly used for COPD in the U.S. since most people can use inhaled bronchodilators. Dyspnea is influenced by both physiologic and psychologic factors. 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